Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer.

ABSTRACT: Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous ovarian cancer. This study used high throughput tools to compare the transcriptome of high grade serous ovarian cancer and normal fallopian tubes in the interest of identifying unique fusion transcripts within each group. Indeed, we found that there were significantly more fusion transcripts in the cancer samples relative to the normal fallopian tubes. Following this, the role of fusion transcripts in chemo-response and overall survival was investigated. This led to the identification of fusion

SUBMITTER: Newtson A 

PROVIDER: S-EPMC8125626 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature