(Dis)Solving the problem of aberrant protein states.
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ABSTRACT:
SUBMITTER: Fare CM
PROVIDER: S-EPMC8126477 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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(Dis)Solving the problem of aberrant protein states.
Fare Charlotte M CM Shorter James J
Disease models & mechanisms 20210504 5
Neurodegenerative diseases and other protein-misfolding disorders represent a longstanding biomedical challenge, and effective therapies remain largely elusive. This failure is due, in part, to the recalcitrant and diverse nature of misfolded protein conformers. Recent work has uncovered that many aggregation-prone proteins can also undergo liquid-liquid phase separation, a process by which macromolecules self-associate to form dense condensates with liquid properties that are compositionally di ...[more]
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