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Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors.

ABSTRACT: Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis, we show that elevated baseline serum IL-8 levels are associated with poor outcome in patients (n = 1,344) with advanced cancers treated with nivolumab and/or ipilimumab, everolimus or docetaxel in phase 3 clinical trials, revealing the importance of assessing serum IL-8 levels in identifying unfavorable tumor immunobiology and as an independent biomarker in patients receiving immune-checkpoint inhibitors.

SUBMITTER: Schalper KA

PROVIDER: S-EPMC8127102 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors.

Schalper Kurt A KA Carleton Michael M Zhou Ming M Chen Tian T Feng Ye Y Huang Shu-Pang SP Walsh Alice M AM Baxi Vipul V Pandya Dimple D Baradet Timothy T Locke Darren D Wu Qiuyan Q Reilly Timothy P TP Phillips Penny P Nagineni Venkata V Gianino Nicole N Gu Jianlei J Zhao Hongyu H Perez-Gracia Jose Luis JL Sanmamed Miguel F MF Melero Ignacio I

Nature medicine 20200511 5

Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis, we show that elevated baseline serum IL-8 levels are associated with poor outcome in patients (n = 1,344) with advanced cancers treated with nivolumab and/or ipilimumab, everolimus or docetaxel in phase 3 clinical trials, revealing the importance of assessing serum IL-8 levels in identifying unfavorable tumor immunobiology ...[more]

PMID: 32405062

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