Population genetic considerations for using biobanks as international resources in the pandemic era and beyond.

ABSTRACT: The past years have seen the rise of genomic biobanks and mega-scale meta-analysis of genomic data, which promises to reveal the genetic underpinnings of health and disease. However, the over-representation of Europeans in genomic studies not only limits the global understanding of disease risk but also inhibits viable research into the genomic differences between carriers and patients. Whilst the community has agreed that more diverse samples are required, it is not enough to blindly increase diversity; the diversity must be quantified, compared and annotated to lead to insight. Genetic annotations from separate biobanks need to be comparable and computable and to operate without access to raw data due to privacy concerns. Comparability is key both for regular research and to allow intern

SUBMITTER: Carress H 

PROVIDER: S-EPMC8127217 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature