Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier.

ABSTRACT: Chagas disease is a neglected tropical disease caused by the flagellate protozoan Trypanosoma cruzi (T. cruzi). Endemic in underdeveloped and developed countries, due to the migratory movement, it is considered a serious public health problem. Endemic in underdeveloped countries and due to the migratory movement, in developed countries as well, it is considered a serious public health problem. One of the reasons for this is a weak therapeutic arsenal, represented only by the drug benznidazole (BNZ) which, although it promotes significant cure rates in the acute phase of the disease, presents serious problems of toxicity and bioavailability, mainly due to its low aqueous solubility. Several studies have presented several drug delivery systems (DDS) based on BNZ aiming at enhancing its solub

SUBMITTER: de Moura Ferraz LR 

PROVIDER: S-EPMC8128829 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature