DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
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ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC8129081 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Liu Lu L Wu Yuqing Y Wang Bingwei B Jiang Yuying Y Lin Lin L Li Xiaoxi X Yang Shuo S
Cell death & disease 20210517 6
The decrease of neurotransmitter dopamine (DA) levels in the intestine is closely related to the development of inflammatory bowel disease (IBD). However, the functional relevance and underlying mechanistic basis of the effects of DA signaling on IBD remains unclear. Here, we observed that the DRD5 receptor is highly expressed in colonic macrophages, and the deficiency of DA-DRD5 signaling exacerbated experimental colitis. Moreover, DA-DRD5 signaling can inhibit M1 by negatively regulating NF-κB ...[more]
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