Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies.

ABSTRACT:

Background

Mitochondria are essential organelles that provide energy for cellular functions, participate in cellular signaling and growth, and facilitate cell death. Based on their multifactorial roles, mitochondria are also critical in the progression of critical illnesses. Transplantation of mitochondria has been reported as a potential promising approach to treat critical illnesses, particularly ischemia reperfusion injury (IRI). However, a systematic review of the relevant literature has not been conducted to date. Here, we systematically reviewed the animal and human studies relevant to IRI to summarize the evidence for mitochondrial transplantation.

Methods

We searched MEDLINE, the Cochrane library, and Embase and performed a systematic review of mitochondrial transpla

SUBMITTER: Hayashida K 

PROVIDER: S-EPMC8130169 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature