Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk.

ABSTRACT:

Aims

We designed a case-control study to investigate the effect of vitamin D receptor gene (VDR) gene single nucleotide polymorphisms (SNPs) and possible gene- environment interaction on the susceptibility of renal cell carcinoma (RCC).

Methods

Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between SNPs and environmental factors, including gene- gene synergy and gene environment synergy effect. Logistic regression was used to analyze the correlation between the four SNPs in VDR gene and RCC, and the significant interaction combinations found by GMDR model were analyzed by hierarchical analysis.

Results

The genotype distribution of the control group was in accordance with Hardy- Weinberg equilibrium. Logistic r

SUBMITTER: Jianhai T 

PROVIDER: S-EPMC8130296 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature