The predictive power of saliva electrolytes exceeds that of saliva microbiomes in diagnosing early childhood caries.

ABSTRACT: Early childhood caries (ECC) is one of the most prevalent chronic diseases affecting children worldwide, and thus its etiology, diagnosis, and prognosis are of particular clinical significance. This study aims to test the ability of salivary microbiome and electrolytes in diagnosing ECC, and their interplays within the same population. We here simultaneously profiled salivary microbiome and biochemical components of 331 children (166 caries-free (H group) and 165 caries-active children (C group)) aged 4-6 years. We identified both salivary microbial and biochemical dysbiosis associated with ECC. Remarkably, K⁺, Cl^-, NH₄ ⁺, Na⁺, SO₄ ^2-, Ca²⁺, Mg²⁺, and Br^- were enriched while pH and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8131007 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature