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ABSTRACT: Background
Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May-June 2020 and 7.1% in August-September 2020. A third serosurvey was conducted between December 2020 and January 2021 to estimate the seroprevalence of SARS-CoV-2 infection among the general population and healthcare workers (HCWs) in India.Methods
The third serosurvey was conducted in the same 70 districts as the first and second serosurveys. For each district, at least 400 individuals aged ≥10 years from the general population and 100 HCWs from subdistrict-level health facilities were enrolled. Serum samples from the general population were tested for the presence of immunoglobulin G (IgG) antibodies against the nucleocapsid (N) and spike (S1-RBD) proteins of SARS-CoV-2, whereas serum samples from HCWs were tested for anti-S1-RBD. Weighted seroprevalence adjusted for assay characteristics was estimated.Results
Of the 28,598 serum samples from the general population, 4585 (16%) had IgG antibodies against the N protein, 6647 (23.2%) had IgG antibodies against the S1-RBD protein, and 7436 (26%) had IgG antibodies against either the N protein or the S1-RBD protein. Weighted and assay-characteristic-adjusted seroprevalence against either of the antibodies was 24.1% [95% confidence interval (CI) 23.0-25.3%]. Among 7385 HCWs, the seroprevalence of anti-S1-RBD IgG antibodies was 25.6% (95% CI 23.5-27.8%).Conclusions
Nearly one in four individuals aged ≥10 years from the general population as well as HCWs in India had been exposed to SARS-CoV-2 by December 2020.
SUBMITTER: Murhekar MV
PROVIDER: S-EPMC8132496 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Murhekar Manoj V MV Bhatnagar Tarun T Thangaraj Jeromie Wesley Vivian JWV Saravanakumar V V Kumar Muthusamy Santhosh MS Selvaraju Sriram S Rade Kiran K Kumar C P Girish CPG Sabarinathan R R Turuk Alka A Asthana Smita S Balachandar Rakesh R Bangar Sampada Dipak SD Bansal Avi Kumar AK Chopra Vishal V Das Dasarathi D Deb Alok Kumar AK Devi Kangjam Rekha KR Dhikav Vikas V Dwivedi Gaurav Raj GR Khan S Muhammad Salim SMS Kumar M Sunil MS Laxmaiah Avula A Madhukar Major M Mahapatra Amarendra A Rangaraju Chethana C Turuk Jyotirmayee J Yadav Rajiv R Andhalkar Rushikesh R Arunraj K K Bharadwaj Dinesh Kumar DK Bharti Pravin P Bhattacharya Debdutta D Bhat Jyothi J Chahal Ashrafjit S AS Chakraborty Debjit D Chaudhury Anshuman A Deval Hirawati H Dhatrak Sarang S Dayal Rakesh R Elantamilan D D Giridharan Prathiksha P Haq Inaamul I Hudda Ramesh Kumar RK Jagjeevan Babu B Kalliath Arshad A Kanungo Srikanta S Krishnan Nivethitha N NN Kshatri Jaya Singh JS Kumar Alok A Kumar Niraj N Kumar V G Vinoth VGV Lakshmi G G J Naga GGJN Mehta Ganesh G Mishra Nandan Kumar NK Mitra Anindya A Nagbhushanam K K Nimmathota Arlappa A Nirmala A R AR Pandey Ashok Kumar AK Prasad Ganta Venkata GV Qurieshi Mariya Amin MA Reddy Sirasanambatti Devarajulu SD Robinson Aby A Sahay Seema S Saxena Rochak R Sekar Krithikaa K Shukla Vijay Kumar VK Singh Hari Bhan HB Singh Prashant Kumar PK Singh Pushpendra P Singh Rajeev R Srinivasan Nivetha N Varma Dantuluri Sheethal DS Viramgami Ankit A Wilson Vimith Cheruvathoor VC Yadav Surabhi S Yadav Suresh S Zaman Kamran K Chakrabarti Amit A Das Aparup A Dhaliwal R S RS Dutta Shanta S Kant Rajni R Khan A M AM Narain Kanwar K Narasimhaiah Somashekar S Padmapriyadarshini Chandrasekaran C Pandey Krishna K Pati Sanghamitra S Patil Shripad S Rajkumar Hemalatha H Ramarao Tekumalla T Sharma Y K YK Singh Shalini S Panda Samiran S Reddy D C S DCS Bhargava Balram B
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20210519
<h4>Background</h4>Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May-June 2020 and 7.1% in August-September 2020. A third serosurvey was conducted between December 2020 and January 2021 to estimate the seroprevalence of SARS-CoV-2 infection among the general population and healthcare workers (HCWs) in India.<h4>Methods</h4>The third serosurvey was conducted in the same 70 districts as the first and second serosurv ...[more]