Unknown

Dataset Information

0

SARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020-January 2021.


ABSTRACT:

Background

Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May-June 2020 and 7.1% in August-September 2020. A third serosurvey was conducted between December 2020 and January 2021 to estimate the seroprevalence of SARS-CoV-2 infection among the general population and healthcare workers (HCWs) in India.

Methods

The third serosurvey was conducted in the same 70 districts as the first and second serosurveys. For each district, at least 400 individuals aged ≥10 years from the general population and 100 HCWs from subdistrict-level health facilities were enrolled. Serum samples from the general population were tested for the presence of immunoglobulin G (IgG) antibodies against the nucleocapsid (N) and spike (S1-RBD) proteins of SARS-CoV-2, whereas serum samples from HCWs were tested for anti-S1-RBD. Weighted seroprevalence adjusted for assay characteristics was estimated.

Results

Of the 28,598 serum samples from the general population, 4585 (16%) had IgG antibodies against the N protein, 6647 (23.2%) had IgG antibodies against the S1-RBD protein, and 7436 (26%) had IgG antibodies against either the N protein or the S1-RBD protein. Weighted and assay-characteristic-adjusted seroprevalence against either of the antibodies was 24.1% [95% confidence interval (CI) 23.0-25.3%]. Among 7385 HCWs, the seroprevalence of anti-S1-RBD IgG antibodies was 25.6% (95% CI 23.5-27.8%).

Conclusions

Nearly one in four individuals aged ≥10 years from the general population as well as HCWs in India had been exposed to SARS-CoV-2 by December 2020.

SUBMITTER: Murhekar MV 

PROVIDER: S-EPMC8132496 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

SARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020-January 2021.

Murhekar Manoj V MV   Bhatnagar Tarun T   Thangaraj Jeromie Wesley Vivian JWV   Saravanakumar V V   Kumar Muthusamy Santhosh MS   Selvaraju Sriram S   Rade Kiran K   Kumar C P Girish CPG   Sabarinathan R R   Turuk Alka A   Asthana Smita S   Balachandar Rakesh R   Bangar Sampada Dipak SD   Bansal Avi Kumar AK   Chopra Vishal V   Das Dasarathi D   Deb Alok Kumar AK   Devi Kangjam Rekha KR   Dhikav Vikas V   Dwivedi Gaurav Raj GR   Khan S Muhammad Salim SMS   Kumar M Sunil MS   Laxmaiah Avula A   Madhukar Major M   Mahapatra Amarendra A   Rangaraju Chethana C   Turuk Jyotirmayee J   Yadav Rajiv R   Andhalkar Rushikesh R   Arunraj K K   Bharadwaj Dinesh Kumar DK   Bharti Pravin P   Bhattacharya Debdutta D   Bhat Jyothi J   Chahal Ashrafjit S AS   Chakraborty Debjit D   Chaudhury Anshuman A   Deval Hirawati H   Dhatrak Sarang S   Dayal Rakesh R   Elantamilan D D   Giridharan Prathiksha P   Haq Inaamul I   Hudda Ramesh Kumar RK   Jagjeevan Babu B   Kalliath Arshad A   Kanungo Srikanta S   Krishnan Nivethitha N NN   Kshatri Jaya Singh JS   Kumar Alok A   Kumar Niraj N   Kumar V G Vinoth VGV   Lakshmi G G J Naga GGJN   Mehta Ganesh G   Mishra Nandan Kumar NK   Mitra Anindya A   Nagbhushanam K K   Nimmathota Arlappa A   Nirmala A R AR   Pandey Ashok Kumar AK   Prasad Ganta Venkata GV   Qurieshi Mariya Amin MA   Reddy Sirasanambatti Devarajulu SD   Robinson Aby A   Sahay Seema S   Saxena Rochak R   Sekar Krithikaa K   Shukla Vijay Kumar VK   Singh Hari Bhan HB   Singh Prashant Kumar PK   Singh Pushpendra P   Singh Rajeev R   Srinivasan Nivetha N   Varma Dantuluri Sheethal DS   Viramgami Ankit A   Wilson Vimith Cheruvathoor VC   Yadav Surabhi S   Yadav Suresh S   Zaman Kamran K   Chakrabarti Amit A   Das Aparup A   Dhaliwal R S RS   Dutta Shanta S   Kant Rajni R   Khan A M AM   Narain Kanwar K   Narasimhaiah Somashekar S   Padmapriyadarshini Chandrasekaran C   Pandey Krishna K   Pati Sanghamitra S   Patil Shripad S   Rajkumar Hemalatha H   Ramarao Tekumalla T   Sharma Y K YK   Singh Shalini S   Panda Samiran S   Reddy D C S DCS   Bhargava Balram B  

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20210519


<h4>Background</h4>Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May-June 2020 and 7.1% in August-September 2020. A third serosurvey was conducted between December 2020 and January 2021 to estimate the seroprevalence of SARS-CoV-2 infection among the general population and healthcare workers (HCWs) in India.<h4>Methods</h4>The third serosurvey was conducted in the same 70 districts as the first and second serosurv  ...[more]

Similar Datasets

| S-EPMC9207578 | biostudies-literature
| S-EPMC10021917 | biostudies-literature
| S-EPMC8726494 | biostudies-literature
| S-EPMC8683266 | biostudies-literature
| S-EPMC10310397 | biostudies-literature
| S-EPMC10233184 | biostudies-literature
| S-EPMC8601780 | biostudies-literature
| S-EPMC8410576 | biostudies-literature
| S-EPMC10106115 | biostudies-literature