Comparison of Balanced Crystalloid Solutions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Objective

To summarize the evidence comparing various balanced crystalloid solutions.

Data sources

We searched MEDLINE, EMBASE, PUBMED, and CENTRAL databases.

Study selection

We included randomized controlled trials that directly compared the IV administration of one balanced crystalloid solution with another.

Data extraction and analysis

We examined metabolic and patient-important outcomes and conducted meta-analysis using random effects model. For comparisons or outcomes with insufficient data to allow for pooling, we describe results narratively. We assessed risk of bias for individual trials using the Cochrane risk of bias tool and certainty of evidence using Grading of Recommendations, Assessment, Development and Evaluations methodology.

Data synthesis<

SUBMITTER: Curran JD 

PROVIDER: S-EPMC8133105 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature