Ontology highlight
ABSTRACT:
SUBMITTER: Locquet MA
PROVIDER: S-EPMC8134575 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Locquet Marie-Anaïs MA Ichim Gabriel G Bisaccia Joseph J Dutour Aurelie A Lebecque Serge S Castets Marie M Weber Kathrin K
Scientific reports 20210519 1
In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease. Here, we demonstrate that in the absence of Caspase-8, activation of TLR3 can trigger a form of programmed cell death, which is distinct from classical apoptosis. When TLR3 was activated in the Caspase-8 negative neuroblastoma cell line SH-SY5Y, cell death was accompanied by lysosomal permeabilization. Despite caspases being activated, lyso ...[more]