Mesenchymal stem cell-conditioned medium attenuates the retinal pathology in amyloid-β-induced rat model of Alzheimer's disease: Underlying mechanisms.
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ABSTRACT: Amyloid-beta (Aβ) oligomer is known to contribute to the pathophysiology of age-related macular degeneration. Herein, we aimed to elucidate the in vivo and in vitro effects of Aβ1-42 application on retinal morphology in rats. Our in vivo studies revealed that intracerebroventricular administration of Aβ1-42 oligomer caused dysmorphological changes in both retinal ganglion cells and retinal pigment epithelium. In addition, in vitro studies revealed that ARPE-19 cells following Aβ1-42 oligomer application had decreased viability along with apoptosis and decreased expression of the tight junction proteins, increased expression of both phosphor-AKT and phosphor-GSK3β and decreased expression of both SIRT1 and β-catenin. Application of conditioned medium (CM) ob
SUBMITTER: Kuo SC
PROVIDER: S-EPMC8135003 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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