Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC8136811 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wang Jing J Sun Na N Lee Yi-Te YT Ni Yiqian Y Koochekpour Rose R Zhu Yazhen Y Tseng Hsian-Rong HR Wang Shuyang S Jiang Liyan L Zhu Hongguang H
Journal of materials chemistry. B 20200701 26
Determining the status of epidermal growth factor receptor (EGFR) T790M mutation is crucial for guiding further treatment intervention in advanced non-small cell lung cancer (NSCLC) patients who develop acquired resistance to initial EGFR tyrosine kinase inhibitor (TKI) treatment. Circulating tumor cells (CTCs) which contain plentiful copies of well-preserved RNA offer an ideal source for noninvasive detection of T790M mutation in NSCLC. We developed a CTC-based digital assay which synergistical ...[more]