FreeHi-C simulates high-fidelity Hi-C data for benchmarking and data augmentation.
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ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC8136837 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
FreeHi-C simulates high-fidelity Hi-C data for benchmarking and data augmentation.
Nature methods 20191111 1
The ability to simulate high-throughput chromatin conformation (Hi-C) data is foundational for benchmarking Hi-C data analysis methods. Here we present a nonparametric strategy named FreeHi-C to simulate Hi-C data from the interacting genome fragments. Data from FreeHi-C exhibit high fidelity to biological Hi-C data. FreeHi-C boosts the precision and power of differential chromatin interaction detection through data augmentation under preserved false discovery rate control. ...[more]
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