MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway.
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ABSTRACT: The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated protein degradation (ERAD) mediated ubiquitin protein degradation of GABAAα1, which was involved in METH addiction. The present study, using qRT-PCR and bioinformatics analysis, further revealed that miR-181a may be indirectly responsible for the METH addiction and downregulation of GABAAα1 through the regulation of ERAD.
SUBMITTER: Wang Y
PROVIDER: S-EPMC8137846 | biostudies-literature |
REPOSITORIES: biostudies-literature
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