Ontology highlight
ABSTRACT:
SUBMITTER: Michaelian N
PROVIDER: S-EPMC8137929 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Michaelian Nairie N Sadybekov Anastasiia A Besserer-Offroy Élie É Han Gye Won GW Krishnamurthy Harini H Zamlynny Beata A BA Fradera Xavier X Siliphaivanh Phieng P Presland Jeremy J Spencer Kerrie B KB Soisson Stephen M SM Popov Petr P Sarret Philippe P Katritch Vsevolod V Cherezov Vadim V
Nature communications 20210520 1
The leukotriene B4 receptor 1 (BLT1) regulates the recruitment and chemotaxis of different cell types and plays a role in the pathophysiology of infectious, allergic, metabolic, and tumorigenic human diseases. Here we present a crystal structure of human BLT1 (hBLT1) in complex with a selective antagonist MK-D-046, developed for the treatment of type 2 diabetes and other inflammatory conditions. Comprehensive analysis of the structure and structure-activity relationship data, reinforced by site- ...[more]