Differential gene expression profile by RNA sequencing study of elderly osteoporotic hip fracture patients with sarcopenia.

ABSTRACT:

Background

The purpose of this study was to report the RNA sequencing profile according to the presence or absence of sarcopenia in elderly patients with osteoporotic hip fracture. Therefore, an important genetic factor candidate for sarcopenia causing hip fracture in elderly with osteoporosis has been identified.

Methods

The patient group involved subjects over 65 years who had undergone hip fracture surgery. Among 323 hip fracture (HF) patients identified from May 2017 to December 2019, 162 HF patients (90 non-sarcopenia and 72 sarcopenia groups), excluding subjects with high energy trauma and non-osteoporosis, were finally included in the analysis. For RNA sequencing, each patient with hand grip strength (HGS) values in the top 10% were enrolled in the control group and w

SUBMITTER: Kang YJ 

PROVIDER: S-EPMC8138673 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature