Ontology highlight
ABSTRACT:
SUBMITTER: Sang JC
PROVIDER: S-EPMC8139990 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Sang Jason C JC Hidari Eric E Meisl Georg G Ranasinghe Rohan T RT Spillantini Maria Grazia MG Klenerman David D
Communications biology 20210521 1
Aggregation of α-synuclein (α-syn) is closely linked to Parkinson's disease (PD) and the related synucleinopathies. Aggregates spread through the brain during the progression of PD, but the mechanism by which this occurs is still not known. One possibility is a self-propagating, templated-seeding mechanism, but this cannot be established without quantitative information about the efficiencies and rates of the key steps in the cellular process. To address this issue, we imaged the uptake and seed ...[more]