Transcriptional signature in microglia associated with Aβ plaque phagocytosis.

ABSTRACT: The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4⁺) and non-containing (XO4^-) microglia from an AD mouse model. Transcriptomics analysis identified different transcriptional trajectories in ageing and AD mice. XO4⁺ microglial transcriptomes demonstrated dysregulated expression of genes associated with late onset AD. We further showed that the transcriptional program associated with XO4⁺ microglia from mice is present in a subset of human microglia isolated from brains of individuals with AD. XO4^- microglia displayed transcriptional signatures associated with accele

SUBMITTER: Grubman A 

PROVIDER: S-EPMC8140091 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature