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Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box.

ABSTRACT: Understanding and treating heterogeneous brain disorders requires specialized techniques spanning genetics, proteomics, and neuroimaging. Designed to meet this need, NeuroPM-box is a user-friendly, open-access, multi-tool cross-platform software capable of characterizing multiscale and multifactorial neuropathological mechanisms. Using advanced analytical modeling for molecular, histopathological, brain-imaging and/or clinical evaluations, this framework has multiple applications, validated here with synthetic (N > 2900), in-vivo (N = 911) and post-mortem (N = 736) neurodegenerative data, and including the ability to characterize: (i) the series of sequential states (genetic, histopathological, imaging or clinical alterations) covering decades of disease progression, (ii) concurrent intra-brain spreading of pathological factors (e.g., amyloid, tau and alpha-synuclein proteins), (iii) synergistic interactions between multiple biological factors (e.g., toxic tau effects on brain atrophy), and (iv) biologically-defined patient stratification based on disease heterogeneity and/or therapeutic needs. This freely available toolbox ( neuropm-lab.com/neuropm-box.html ) could contribute significantly to a better understanding of complex brain processes and accelerating the implementation of Precision Medicine in Neurology.

SUBMITTER: Iturria-Medina Y

PROVIDER: S-EPMC8140107 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box.

Iturria-Medina Yasser Y Carbonell Félix F Assadi Atousa A Adewale Quadri Q Khan Ahmed F AF Baumeister Tobias R TR Sanchez-Rodriguez Lazaro L

Communications biology 20210521 1

Understanding and treating heterogeneous brain disorders requires specialized techniques spanning genetics, proteomics, and neuroimaging. Designed to meet this need, NeuroPM-box is a user-friendly, open-access, multi-tool cross-platform software capable of characterizing multiscale and multifactorial neuropathological mechanisms. Using advanced analytical modeling for molecular, histopathological, brain-imaging and/or clinical evaluations, this framework has multiple applications, validated here ...[more]

PMID: 34021244

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Dataset Information

Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box.

Publications

Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box.

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