Unknown

Dataset Information

0

Peripheral and lung resident memory T cell responses against SARS-CoV-2.


ABSTRACT: Resident memory T cells (TRM) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, TRM are mostly non-recirculating, which reduces the window of opportunity to examine these cells in the blood as they move to the lung parenchyma. Here, we identify circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome. Disease severity is associated predominantly with IFNγ and IL-4 responses, increased responses against S peptides and apoptosis, whereas non-hospitalized patients have increased IL-12p70 levels, degranulation in response to N peptides and SARS-CoV-2-specific CCR7+ T cells secreting IL-10. In convalescent patients, lung-TRM are frequently detected even 10 months after initial infection, in which contemporaneous blood does not reflect tissue-resident profiles. Our study highlights a balanced anti-inflammatory antiviral response associated with a better outcome and persisting TRM cells as important for future protection against SARS-CoV-2 infection.

SUBMITTER: Grau-Exposito J 

PROVIDER: S-EPMC8140108 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10074357 | biostudies-literature
2023-08-08 | GSE230398 | GEO
| S-EPMC5120139 | biostudies-literature
| S-EPMC8159694 | biostudies-literature
| S-EPMC7730020 | biostudies-literature
| S-EPMC9958580 | biostudies-literature
| S-SCDT-10_1038-S44318-024-00061-0 | biostudies-other
| S-EPMC8825652 | biostudies-literature
| S-EPMC8578432 | biostudies-literature
| S-EPMC8967717 | biostudies-literature