Ontology highlight
ABSTRACT:
SUBMITTER: Wang TY
PROVIDER: S-EPMC8141048 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Wang Ting-You TY Liu Qi Q Ren Yanan Y Alam Sk Kayum SK Wang Li L Zhu Zhu Z Hoeppner Luke H LH Dehm Scott M SM Cao Qi Q Yang Rendong R
Molecular cell 20210415 10
Exitron splicing (EIS) creates a cryptic intron (called an exitron) within a protein-coding exon to increase proteome diversity. EIS is poorly characterized, but emerging evidence suggests a role for EIS in cancer. Through a systematic investigation of EIS across 33 cancers from 9,599 tumor transcriptomes, we discovered that EIS affected 63% of human coding genes and that 95% of those events were tumor specific. Notably, we observed a mutually exclusive pattern between EIS and somatic mutations ...[more]