Anomalous Laterally Stressed Kinetically Trapped DNA Surface Conformations.

ABSTRACT:

Highlights

DNA kinking is inevitable for the highly anisotropic 1D-1D electrostatic interaction with the one-dimensionally periodically charged surface. The double helical structure of the DNA kinetically trapped on positively charged monomolecular films comprising the lamellar templates is strongly laterally stressed and extremely perturbed at the nanometer scale. The DNA kinetic trapping is not a smooth 3D-> 2D conformational flattening but is a complex nonlinear in-plane mechanical response (bending, tensile and unzipping) driven by the physics beyond the scope of the applicability of the linear worm-like chain approximation. Up to now, the DNA molecule adsorbed on a surface was believed to always preserve its native structure. This belief implies a negligible contribution of la

SUBMITTER: Prokhorov VV 

PROVIDER: S-EPMC8141082 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature