DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis.

ABSTRACT:

Background

Ovarian cancer is the most fatal gynecological malignancy. Owing to its insidious onset, rapid development, and poor prognosis, ovarian cancer is the fifth most common cause of death in women. Although immunotherapy-related drugs, such as Olaparib, can alleviate ovarian cancer progression, there are no remarkable breakthroughs for its effective treatment. It is considered that the transformation of normal cells to cancerous ones involves "recoding" of certain metabolic pathways. Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis. However, the role of DGAT1 in ovarian cancer is not yet elucidated.

Materials and methods

We analyzed the correlation between DGAT1

SUBMITTER: Xia L 

PROVIDER: S-EPMC8141271 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature