Project description:Immunosuppression caused by cancer itself and cytotoxic treatment may pose a challenge to coronavirus disease 2019 (COVID-19) patients with hematological malignancies. Here, we use multidimensional flow cytometry (MFC) to analyze immune profiles in peripheral blood samples of 515 COVID-19 patients at presentation. In 14 cases, deep immunophenotyping of B- and T-cells was performed and six myeloid- and dendritic-cell subsets were FACSorted for transcriptome analysis using RNAseq. Of the 515 patients, 15 and 10 had solid and hematological tumors, respectively. Those with hematological cancer showed significantly higher rates of intensive care (50%) and death (30%) from COVID-19 vs cases with solid cancer and no tumor. Patients with hematological malignancies displayed altered immune profiles with significantly decreased absolute numbers of several subsets of myeloid and lymphoid cells. Myeloid- and dendritic-cell types from hematological cases showed differentially expression of genes coding transcription factors, toll-like receptors and proinflammatory interleukin receptors implicated in response to coronaviruses. The relative distribution of the B-cell compartment was notoriously altered in COVID-19 patients with hematological cancer, and progressively lower numbers of B- and T-cell subsets were observed in deceased cases. Altogether, our results suggest an association between impaired immune responses and poorer outcomes in COVID-19 patients with hematological malignancies.

2020-12-31 | GSE153610 | GEO

Vitamin D binding protein: A polymorphic protein with actin-binding capacity in COVID-19.

Project description: Not available

| S-EPMC8129783 | biostudies-literature

Vitamin D and Vitamin D binding protein: the inseparable duo in COVID-19.

Project description: Not available

| S-EPMC8038533 | biostudies-literature

Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19.

Project description: Not available

| S-EPMC7861048 | biostudies-literature

Vitamin D-Binding protein Gene Polymorphism Predicts

Project description:Background: Vitamin D deficiency is related to poor clinical outcomes in patients with chronic hepatitis B virus

| S-EPMC6948901 | biostudies-literature

A key role for vitamin D binding protein in COVID-19?

Project description: Not available

| S-EPMC7882234 | biostudies-literature

A genetic insight into vitamin D binding protein and COVID-19.

Project description:It's since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern. A "pandemic"; this is what WHO has declared about the COVID-19 outbreak on March 3rd, 2020. Vitamin D and its deficiency have recently been claimed to be one of the potential factors affecting COVID-19 risks and outcomes [1]. As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I'd believe that vitamin D binding protein (DBP) is maybe also involved. A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.

| S-EPMC7871104 | biostudies-literature

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