Manganese silicate nanospheres-incorporated hydrogels：starvation therapy and tissue regeneration.

ABSTRACT: To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Taking advantage of the catalytic activity of Mn ions, the composite hydrogels could decompose hydrogen peroxide (H₂O₂) into oxygen (O₂), which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O₂ for tumor starvation. Meanwhile, hyperthermia triggered by near infrared

SUBMITTER: Ma H 

PROVIDER: S-EPMC8141607 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature