Pan-cancer characterization of metabolism-related biomarkers identifies potential therapeutic targets.

ABSTRACT:

Background

Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical metabolic pathways, glycolysis and oxidative phosphorylation (OXPHOS), remains poorly defined.

Methods

We developed a "double-score" system to quantify glycolysis and OXPHOS in 9668 patients across 33 tumor types from The Cancer Genome Atlas and classified them into four metabolic subtypes. Multi-omics bioinformatical analyses was conducted to detect metabolism-related molecular features.

Results

Compared with patients with low glycolysis and high OXPHOS (LGHO), those with high glycolysis and low OXPHOS (HGLO) were consistently associated with worse pr

SUBMITTER: Bi G 

PROVIDER: S-EPMC8142489 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature