Understanding FBA Solutions under Multiple Nutrient Limitations.
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ABSTRACT:
SUBMITTER: van Pelt-KleinJan E
PROVIDER: S-EPMC8143296 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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Understanding FBA Solutions under Multiple Nutrient Limitations.
van Pelt-KleinJan Eunice E de Groot Daan H DH Teusink Bas B
Metabolites 20210421 5
Genome-scale stoichiometric modeling methods, in particular Flux Balance Analysis (FBA) and variations thereof, are widely used to investigate cell metabolism and to optimize biotechnological processes. Given (1) a metabolic network, which can be reconstructed from an organism's genome sequence, and (2) constraints on reaction rates, which may be based on measured nutrient uptake rates, FBA predicts which reactions maximize an objective flux, usually the production of cell components. Although F ...[more]
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