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Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications.

ABSTRACT: Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota-tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits.

SUBMITTER: Sallam IE

PROVIDER: S-EPMC8145700 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications.

Sallam Ibrahim E IE Abdelwareth Amr A Attia Heba H Aziz Ramy K RK Homsi Masun Nabhan MN von Bergen Martin M Farag Mohamed A MA

Microorganisms 20210429 5

Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effec ...[more]

PMID: 33947064

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Dataset Information

Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications.

Publications

Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications.

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