Integrative Systems Biology Approaches to Identify Potential Biomarkers and Pathways of Cervical Cancer.

ABSTRACT: Nowadays, cervical cancer (CC) is treated as the leading cancer among women throughout the world. Despite effective vaccination and improved surgery and treatment, CC retains its fatality rate of about half of the infected population globally. The major screening biomarkers and therapeutic target identification have now become a global concern. In the present study, we have employed systems biology approaches to retrieve the potential biomarkers and pathways from transcriptomic profiling. Initially, we have identified 76 of each up-regulated and down-regulated gene from a total of 4643 differentially expressed genes. The up-regulatory genes mainly concentrate on immune-inflammatory responses, and the down-regulatory genes are on receptor binding and gamma-glutamyltransferase. The involved

SUBMITTER: Oany AR 

PROVIDER: S-EPMC8147030 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature