AGMO Inhibitor Reduces 3T3-L1 Adipogenesis.
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ABSTRACT:
SUBMITTER: Fischer C
PROVIDER: S-EPMC8147360 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
AGMO Inhibitor Reduces 3T3-L1 Adipogenesis.
Fischer Caroline C Wilken-Schmitz Annett A Hernandez-Olmos Victor V Proschak Ewgenij E Stark Holger H Fleming Ingrid I Weigert Andreas A Thurn Manuela M Hofmann Martine M Werner Ernst R ER Geisslinger Gerd G Niederberger Ellen E Watschinger Katrin K Tegeder Irmgard I
Cells 20210501 5
Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids. The present study describes the disclosure and biological characterization of a candidate compound (Cp6), which inhibits AGMO with an IC50 of 30-100 µM and 5-20-fold preference of AGMO relative to other BH4-dependent enzymes, i.e., phenylalanine-hydroxylase and nitric oxide synthase. The viability and metabolic acti ...[more]
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