MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis.
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ABSTRACT: Background
This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis.Materials & methods
Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc's criteria.Results
The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation.Conclusion
miR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.
SUBMITTER: Kiyoshima C
PROVIDER: S-EPMC8147753 | biostudies-literature |
REPOSITORIES: biostudies-literature
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