Prognostic implications of PD-L1 expression in patients with angiosarcoma.
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ABSTRACT: Aim
There are limited data on the feasibility of programmed death ligand-1 (PD-L1) expression as a prognostic biomarker in metastatic angiosarcoma.Patients & methods
We retrospectively collected and analyzed the data on PD-L1 expression in 70 angiosarcoma patients who were diagnosed at our center between 2005 and 2019.Results
Thirteen (19%) patients had PD-L1 expression. Metastatic angiosarcoma patients who were PD-L1-negative (n = 24) showed longer median progression-free survival (4.9 vs 1.6 months; p = 0.04) and median overall survival (OS; 10.9 vs 5.4 months; p = 0.01) than those who were PD-L1-positive (n = 4). PD-L1 status proved to be a significant factor for OS.Conclusion
Metastatic angiosarcoma patients with PD-L1 expression showed shorter survival. PD-L1 status is an independent prognostic factor for OS in metastatic angiosarcoma patients.
SUBMITTER: Lee JB
PROVIDER: S-EPMC8147824 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Prognostic implications of PD-L1 expression in patients with angiosarcoma.
Lee Jii Bum JB Ahn Beung-Chul BC Kim Seung Hyun SH Lee Young Han YH Han Jung Woo JW Jeon Min Kyung MK Kim Soo Hee SH Kim Hyo Song HS
Future science OA 20210302 5
<h4>Aim</h4>There are limited data on the feasibility of programmed death ligand-1 (PD-L1) expression as a prognostic biomarker in metastatic angiosarcoma.<h4>Patients & methods</h4>We retrospectively collected and analyzed the data on PD-L1 expression in 70 angiosarcoma patients who were diagnosed at our center between 2005 and 2019.<h4>Results</h4>Thirteen (19%) patients had PD-L1 expression. Metastatic angiosarcoma patients who were PD-L1-negative (n = 24) showed longer median progression-fre ...[more]
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