A H₂O₂ self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy.

ABSTRACT: Chemodynamic therapy (CDT), employing Fenton or Fenton-like catalysts to convert hydrogen peroxide (H₂O₂) into toxic hydroxyl radicals (˙OH) to kill cancer cells, holds high promise in tumor therapy due to its high selectivity. However, the anticancer efficacy is unsatisfactory owing to the limited concentration of endogenous H₂O₂. Herein, thermal responsive nanoparticles with H₂O₂ self-sufficiency are fabricated by utilizing organic phase change materials (PCMs) to encapsulate iron-gallic acid nanoparticles (Fe-GA) and ultra-small CaO₂. PCMs, acting as the gatekeeper, could be melted down by the hyperthermia effect of Fe-GA under laser irradiation with a burst release of Fe-GA and CaO₂. The acidic tumo

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8148300 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature