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A general method for site-selective Csp³-S bond formation via cooperative catalysis.

ABSTRACT: Herein, we report a copper-catalysed site-selective thiolation of Csp³-H bonds of aliphatic amines. The method features a broad substrate scope and good functional group compatibility. Primary, secondary, and tertiary C-H bonds can be converted into C-S bonds with a high efficiency. The late-stage modification of biologically active compounds by this method was also demonstrated. Furthermore, the one-pot preparation of pyrrolidine or piperidine compounds via a domino process was achieved.

SUBMITTER: Qin Y

PROVIDER: S-EPMC8148391 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Automated iterative Csp3-C bond formation.

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Solid-Phase Peptide Modification via Deaminative Photochemical Csp3 -Csp3 Bond Formation Using Katritzky Salts.

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