Dataset Information

Intratumoral CXCR5⁺CD8⁺T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.

ABSTRACT: Studies that examined an association between CD8⁺T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5⁺CD8⁺T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5⁺CD8⁺T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5⁺CD8⁺T cell infiltration are more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable and Epstein-Barr virus positive tumors are enriched with CXCR5⁺CD8⁺T cells. Gastric cancer infiltrating CXCR5⁺CD8⁺T cells represent a specific subtype of stem-like CD8⁺T with effector memory feature. Identification of the clinical significance and phenotype of gastric cancer infiltrating CXCR5⁺CD8⁺T provides a roadmap for patient stratification and trials of targeted therapies.

SUBMITTER: Wang J

PROVIDER: S-EPMC8149695 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.

Wang Jieti J Li Ruochen R Cao Yifan Y Gu Yun Y Fang Hanji H Fei Yuchao Y Lv Kunpeng K He Xudong X Lin Chao C Liu Hao H Zhang Heng H Li He H He Hongyong H Xu Jiejie J Huang Hua H

Nature communications 20210525 1

Studies that examined an association between CD8+T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5+CD8+T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5+CD8+T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5<s ...[more]

PMID: 34035252

Similar Datasets

Project description:BackgroundThe role of CD161 expression on CD8+ T cells in tumor immunology has been explored in a few studies, and the clinical significance of CD161+CD8+ T cells in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study seeks to clarify the prognostic value and molecular characteristics linked to CD161+CD8+ T cell infiltration in PDAC.MethodsThis study included 186 patients with confirmed PDAC histology after radical resection. CD161+CD8+ T cell infiltration was assessed using immunofluorescence staining on tumor microarrays. Flow cytometry and single-cell RNA sequencing were used to evaluate their functional status.ResultsWe observed significant associations between tumor-infiltrating CD161+CD8+ T cells and clinicopathological factors, such as tumor differentiation, perineural invasion, and serum CA19-9 levels. Patients with higher tumor-infiltrating CD161+CD8+ T cell levels had longer overall survival (OS) and recurrence-free survival (RFS) than those with lower levels. Multivariable analysis confirmed tumor-infiltrating CD161+CD8+ T cell as an independent prognostic indicator for both OS and RFS. Notably, a combination of tumor-infiltrating CD161+CD8+ T cell and CA19-9 levels showed a superior power for survival prediction, and patients with low tumor-infiltrating CD161+CD8+ T cell and high CA19-9 levels had the worst survival. Furthermore, lower tumor-infiltrating CD161+CD8+ T cells were associated with a better response to adjuvant chemotherapy. Finally, we identified tumor-infiltrating CD161+CD8+ T cells as a unique subtype of responsive CD8+ T cells characterized by increased levels of cytotoxic cytokines and immune checkpoint molecules.ConclusionCD161+CD8+ T cells exhibit elevated levels of both cytotoxic and immune-checkpoint molecules, indicating as a potential and attractive target for immunotherapy. The tumor-infiltrating CD161+CD8+ T cell is a valuable and promising predictor for survival and therapeutic response to adjuvant chemotherapy in PDAC. Further research is warranted to validate its role in the risk stratification and optimization of therapeutic strategies.

Dataset Information

Intratumoral CXCR5⁺CD8⁺T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.

Publications

Intratumoral CXCR5<sup>+</sup>CD8<sup>+</sup>T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets