Essential genes from genome-wide screenings as a resource for neuropsychiatric disorders gene discovery.

ABSTRACT: Genome-wide screenings of "essential genes", i.e., genes required for an organism or cell survival, have been traditionally conducted in vitro in cancer cell lines, limiting the translation of results to other tissues and non-cancerous cells. Recently, an in vivo screening was conducted in adult mouse striatum tissue, providing the first genome-wide dataset of essential genes in neuronal cells. Here, we aim to investigate the role of essential genes in brain development and disease risk with a comprehensive set of bioinformatics tools, including integration with transcriptomic data from developing human brain, publicly available data from genome-wide association studies, de novo mutation datasets for different neuropsychiatric disorders, and case-control transcriptomic data from postmortem

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8149887 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature