Differences in Maturation Status and Immune Phenotypes of Circulating Helios⁺ and Helios^- Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals.

ABSTRACT: CD4 Tregs are involved in the regulation of various autoimmune diseases but believed to be highly heterogeneous. Studies have indicated that Helios controls a distinct subset of functional Tregs. However, the immunological changes in circulating Helios⁺ and Helios^- Tregs are not fully explored in type 1 diabetes (T1D). Here, we elucidated the differences in maturation status and immune regulatory phenotypes of Helios⁺ and Helios^- Tregs and their correlations with monocyte subsets in T1D individuals. As CD25^-/low FOXP3⁺ Tregs also represent a subset of functional Tregs, we defined Tregs as FOXP3⁺CD127^-/low and examined circulating Helios⁺ and Helios^- Treg subpopulations in 68 autoan

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8149963 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature