Tutorial on Biostatistics: Longitudinal Analysis of Correlated Continuous Eye Data.

ABSTRACT:

Purpose

To describe and demonstrate methods for analyzing longitudinal correlated eye data with a continuous outcome measure.

Methods

We described fixed effects, mixed effects and generalized estimating equations (GEE) models, applied them to data from the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) and the Age-Related Eye Disease Study (AREDS). In CAPT (N = 1052), we assessed the effect of eye-specific laser treatment on change in visual acuity (VA). In the AREDS study, we evaluated effects of systemic supplement treatment among 1463 participants with AMD category 3.

Results

In CAPT, the inter-eye correlations (0.33 to 0.53) and longitudinal correlations (0.31 to 0.88) varied. There was a small treatment effect on VA change (approximatel

SUBMITTER: Ying GS 

PROVIDER: S-EPMC8150110 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature