TreeMap: a structured approach to fine mapping of eQTL variants.

ABSTRACT:

Motivation

Expression quantitative trait loci (eQTL) harbor genetic variants modulating gene transcription. Fine mapping of regulatory variants at these loci is a daunting task due to the juxtaposition of causal and linked variants at a locus as well as the likelihood of interactions among multiple variants. This problem is exacerbated in genes with multiple cis-acting eQTL, where superimposed effects of adjacent loci further distort the association signals.

Results

We developed a novel algorithm, TreeMap, that identifies putative causal variants in cis-eQTL accounting for multisite effects and genetic linkage at a locus. Guided by the hierarchical structure of linkage disequilibrium, TreeMap performs an organized search for individual and multiple causal variants. Via exten

SUBMITTER: Liu L 

PROVIDER: S-EPMC8150140 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature