High Flow Oxygen Therapy at Two Initial Flow Settings versus Conventional Oxygen Therapy in Cardiac Surgery Patients with Postextubation Hypoxemia: A Single-Center, Unblinded, Randomized, Controlled Trial.

ABSTRACT: In cardiac surgery patients with pre-extubation PaO₂/inspired oxygen fraction (FiO₂) < 200 mmHg, the possible benefits and optimal level of high-flow nasal cannula (HFNC) support are still unclear; therefore, we compared HFNC support with an initial gas flow of 60 or 40 L/min and conventional oxygen therapy. Ninety nine patients were randomly allocated (respective ratio: 1:1:1) to I = intervention group 1 (HFNC initial flow = 60 L/min, FiO₂ = 0.6), intervention group 2 (HFNC initial flow = 40 L/min, FiO₂ = 0.6), or control group (Venturi mask, FiO₂ = 0.6). The primary outcome was occurrence of treatment failure. The baseline characteristics were similar. The hazard for treatment failure was lower in intervention group 1 vs. control (ha

SUBMITTER: Theologou S 

PROVIDER: S-EPMC8151420 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature