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Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies.

ABSTRACT: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has been recently considered a systemic disorder leading to the procoagulant state. Preliminary studies have shown that SARS-CoV-2 can infect endothelial cells, and extensive evidence of inflammation and endothelial dysfunction has been found in advanced COVID-19. Endothelial cells play a critical role in many physiological processes, such as controlling blood fluidity, leukocyte activation, adhesion, platelet adhesion and aggregation, and transmigration. Therefore, it is reasonable to think that endothelial dysfunction leads to vascular dysfunction, immune thrombosis, and inflammation associated with COVID-19. This article summarizes the association of endothelial dysfunction and SARS-CoV-2 infection and its therapeutic strategies.

SUBMITTER: Deng H

PROVIDER: S-EPMC8151812 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies.

Deng Hai H Tang Ting-Xuan TX Chen Deng D Tang Liang-Sheng LS Yang Xiang-Ping XP Tang Zhao-Hui ZH

Pathogens (Basel, Switzerland) 20210511 5

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has been recently considered a systemic disorder leading to the procoagulant state. Preliminary studies have shown that SARS-CoV-2 can infect endothelial cells, and extensive evidence of inflammation and endothelial dysfunction has been found in advanced COVID-19. Endothelial cells play a critical role in many physiological processes, such as controlling blood fluidity, leukocyte activati ...[more]

PMID: 34064553

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