Visual Body Part Representation in the Lateral Occipitotemporal Cortex in Children/Adolescents and Adults.
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ABSTRACT:
SUBMITTER: Okamoto Y
PROVIDER: S-EPMC8152859 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:The prevailing view of human lateral occipitotemporal cortex (LOTC) organization suggests a single area selective for images of the human body (extrastriate body area, EBA) that highly overlaps with the human motion-selective complex (hMT+). Using functional magnetic resonance imaging with higher resolution (1.5mm voxels) than past studies (3-4mm voxels), we examined the fine-scale spatial organization of these activations relative to each other, as well as to visual field maps in LOTC. Rather than one contiguous EBA highly overlapping hMT+, results indicate three limb-selective activations organized in a crescent surrounding hMT+: (1) an activation posterior to hMT+ on the lateral occipital sulcus/middle occipital gyrus (LOS/MOG) overlapping the lower vertical meridian shared between visual field maps LO-2 and TO-1, (2) an activation anterior to hMT+ on the middle temporal gyrus (MTG) consistently overlapping the lower vertical meridian of TO-2 and extending outside presently defined visual field maps, and (3) an activation inferior to hMT+ on the inferotemporal gyrus (ITG) overlapping the parafoveal representation of the TO cluster. This crescent organization of limb-selective activations surrounding hMT+ is reproducible over a span of three years and is consistent across different image types used for localization. Further, these regions exhibit differential position properties: preference for contralateral image presentation decreases and preference for foveal presentation increases from the limb-selective LOS to the MTG. Finally, the relationship between limb-selective activations and visual field maps extends to the dorsal stream where a posterior IPS activation overlaps V7. Overall, our measurements demonstrate a series of LOTC limb-selective activations that 1) have separate anatomical and functional boundaries, 2) overlap distinct visual field maps, and 3) illustrate differential position properties. These findings indicate that category selectivity alone is an insufficient organization principle for defining brain areas. Instead, multiple properties are necessary in order to parcellate and understand the functional organization of high-level visual cortex.
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Project description:Previous work using functional magnetic resonance imaging has shown that the identities of isolated objects viewed by human subjects can be extracted from distributed patterns of brain activity. Outside the laboratory, however, objects almost never appear in isolation; thus it is important to understand how multiple simultaneously occurring objects are encoded by the visual system. We used multivoxel pattern analysis to examine this issue, testing whether activity patterns in the lateral occipital complex (LOC) evoked by object pairs showed an ordered relationship to patterns evoked by their constituent objects. Applying a searchlight analysis to identify voxels with the highest signal-to-noise ratios, we found that responses to object pairs within these informative voxels were well predicted by the averages of responses to their constituent objects. Consistent with this result, we were able to classify object pairs by using synthetic patterns created by averaging single-object patterns. These results indicate that the representation of multiple objects in LOC is governed by a response normalization mechanism similar to that reported in visual areas of several nonhuman species. They also suggest a population coding scheme that preserves information about multiple objects under conditions of distributed attention, facilitating fast object and scene recognition during natural vision.
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Project description:How neural specificity for distinct conceptual knowledge categories arises is central for understanding the organization of semantic memory in the human brain. Although there is a large body of research on the neural processing of distinct object categories, the organization of action categories remains largely unknown. In particular, it is unknown whether different action categories follow a specific topographical organization on the cortical surface analogously to the category-specific organization of object knowledge. Here, we tested whether the neural representation of action knowledge is organized in terms of nonsocial versus social and object-unrelated versus object-related actions (sociality and transitivity, respectively, hereafter). We hypothesized a major distinction of sociality and transitivity along dorsal and ventral lateral occipitotemporal cortex (LOTC), respectively. Using fMRI-based multivoxel pattern analysis, we identified neural representations of action information associated with sociality and transitivity in bilateral LOTC. Representational similarity analysis revealed a dissociation between dorsal and ventral LOTC. We found that action representations in dorsal LOTC are segregated along features of sociality, whereas action representations in ventral LOTC are segregated along features of transitivity. In addition, representations of sociality and transitivity features were found more anteriorly in LOTC than representations of specific subtypes of actions, suggesting a posterior-anterior gradient from concrete to abstract action features. These findings elucidate how the neural representations of perceptually and conceptually diverse actions are organized in distinct subsystems in the LOTC.Significance statementThe lateral occipitotemporal cortex (LOTC) is critically involved in the recognition of objects and actions, but our knowledge about the underlying organizing principles is limited. Here, we discovered a dorsal-ventral distinction of actions in LOTC: dorsal LOTC represents actions based on sociality (how much an action is directed to another person) in proximity to person knowledge. In contrast, ventral LOTC represents actions based on transitivity (how much an action involves the interaction with inanimate objects) in proximity to tools/artifacts in ventral LOTC, suggesting a mutually dependent organization of actions and objects. In addition, we found a posterior-to-anterior organization of the LOTC for concrete and abstract representations, respectively. Our findings provide important insights about the organization of actions in LOTC.
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Project description:Mammals are highly skilled in rapidly detecting objects in cluttered natural environments, a skill necessary for survival. What are the neural mechanisms mediating detection of objects in natural scenes? Here, we use human brain imaging to address the role of top-down preparatory processes in the detection of familiar object categories in real-world environments. Brain activity was measured while participants were preparing to detect highly variable depictions of people or cars in natural scenes that were new to the participants. The preparation to detect objects of the target category, in the absence of visual input, evoked activity patterns in visual cortex that resembled the response to actual exemplars of the target category. Importantly, the selectivity of multivoxel preparatory activity patterns in object-selective cortex (OSC) predicted target detection performance. By contrast, preparatory activity in early visual cortex (V1) was negatively related to search performance. Additional behavioral results suggested that the dissociation between OSC and V1 reflected the use of different search strategies, linking OSC preparatory activity to relatively abstract search preparation and V1 to more specific imagery-like preparation. Finally, whole-brain searchlight analyses revealed that, in addition to OSC, response patterns in medial prefrontal cortex distinguished the target categories based on the search cues alone, suggesting that this region may constitute a top-down source of preparatory activity observed in visual cortex. These results indicate that in naturalistic situations, when the precise visual characteristics of target objects are not known in advance, preparatory activity at higher levels of the visual hierarchy selectively mediates visual search.
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Project description:The original Barbie doll's unrealistic body shape can negatively affect young girls' body image. Mattel produced new Barbie dolls with "tall", "curvy", and "petite" body types, yet how girls perceive and evaluate the three new Barbie body types remains unknown. This study investigated whether young girls engage in an automatic "self-other matching" process when viewing the different Barbie doll representations. Female children and adolescents (N = 38; Mage = 10; 6-14 years old; SD = 2.24 years) completed a body-part compatibility task to provide an index of how they implicitly relate cognitive representations of their own body to the different doll images. Significant (p < .05) body-part compatibility effects emerged for the original, curvy and petite dolls, but not for the tall Barbie. These findings indicate that girls engage in a self-other body matching process when viewing Barbie, but that the strength of this matching is influenced by the doll's body type. Results provide new evidence on the underlying cognitive mechanisms that occur when girls are exposed to physique-salient toys, and may have implications for young girls' body image development and use of appearance-based social comparisons.
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Project description:The lateral occipito-temporal cortex (LOTC), including the extrastriate body area, is known to be involved in the perception of body parts. Although still controversial, recent studies have demonstrated the role of the LOTC in higher-level body-related cognition in humans. This study consisted of two experiments (E1 and E2). The first (E1) was an exploratory experiment to find the neural correlate of the mental manipulation of body part imagery, in which brain cerebral glucose metabolic rates and the performance of mental rotation of the hand were measured in 100 subjects who exhibited a range of symptoms of cognitive decline. In E1, we found that the level of glucose metabolism in the right LOTC was significantly correlated with performance in a task involving mental manipulation of the hand. Next, in E2, we performed a randomized, double-blind, controlled intervention study (clinical trial number: UMIN 000018310) in younger healthy adults to test whether right occipital (corresponding to the right LOTC) anodal stimulation using transcranial direct current stimulation (tDCS) could enhance the mental manipulation of the hand. In E2, we demonstrated a significant effect of tDCS on the accuracy rate in a task involving mental manipulation of the hand. Although further study is necessary to answer the question of whether these results are specific for the mental manipulation of body parts but not non-body parts, E1 demonstrated a possible role of the LOTC in carrying out the body mental manipulation task in patients with dementia, and E2 suggested the possible effect of tDCS on this task in healthy subjects.
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