The Role of the Rodent Lateral Orbitofrontal Cortex in Simple Pavlovian Cue-Outcome Learning Depends on Training Experience.

ABSTRACT: The orbitofrontal cortex (OFC) is a critical structure in the flexible control of value-based behaviors. OFC dysfunction is typically only detected when task or environmental contingencies change, against a backdrop of apparently intact initial acquisition and behavior. While intact acquisition following OFC lesions in simple Pavlovian cue-outcome conditioning is often predicted by models of OFC function, this predicted null effect has not been thoroughly investigated. Here, we test the effects of lesions and temporary muscimol inactivation of the rodent lateral OFC on the acquisition of a simple single cue-outcome relationship. Surprisingly, pretraining lesions significantly enhanced acquisition after overtraining, whereas post-training lesions and inactivation significantly impaired acqu

SUBMITTER: Panayi MC 

PROVIDER: S-EPMC8152875 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature