Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation.

ABSTRACT: The dendritic spines of pyramidal cells are the main postsynaptic target of excitatory glutamatergic synapses. Morphological alterations have been described in hippocampal dendritic spines during hibernation-a state of inactivity and metabolic depression that occurs via a transient neuronal tau hyperphosphorylation. Here, we have used the hibernating Syrian hamster to investigate the effect of hyperphosphorylated tau regarding neocortical neuronal structure. In particular, we examined layer Va pyramidal neurons. Our results indicate that hibernation does not promote significant changes in dendritic spine density. However, tau hyperphosphorylated neurons show a decrease in complexity, an increase in the tortuosity of the apical dendrites, and an increase in the diameter of the basal dendrit

SUBMITTER: Regalado-Reyes M 

PROVIDER: S-EPMC8152943 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature