Dataset Information

Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control.

ABSTRACT: Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of "imaging omics." Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromised Balance scores to elevated microRNA (miRNA) levels. rCBF acted as a consistent mediator variable (Sobel's test P < 0.05) between abnormal miRNA levels and compromised Balance scores. Given the involvement of these miRNAs in inflammation and immune function and that vascular perfusion is a component of the inflammatory response, these findings support a chronic inflammatory model in these athletes with 11 years of average football exposure. rCBF, a systems biology measure, was necessary for miRNA to affect behavior.

SUBMITTER: Chen Y

PROVIDER: S-EPMC8153038 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control.

Chen Yufen Y Herrold Amy A AA Martinovich Zoran Z Bari Sumra S Vike Nicole L NL Blood Anne J AJ Walter Alexa E AE Harezlak Jaroslaw J Seidenberg Peter H PH Bhomia Manish M Knollmann-Ritschel Barbara B Stetsiv Khrystyna K Reilly James L JL Nauman Eric A EA Talavage Thomas M TM Papa Linda L Slobounov Semyon S Breiter Hans C HC

Cerebral cortex communications 20201026 1

Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of "imaging omics." Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromi ...[more]

PMID: 34296137

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Dataset Information

Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control.

Publications

Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control.

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