Browse
Submit Data
Databases
API
Help

Dataset Information

20 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-Step Application of Polyelectrolyte Complex Films as Oxygen Barrier Coatings.

ABSTRACT: Polyelectrolyte complex (PEC) films such as polyelectrolyte multilayers have demonstrated excellent oxygen barrier properties, but unfortunately, the established layer-by-layer approaches are laborious and difficult to scale up. Here, we demonstrate a novel single-step approach to produce a PEC film, based on the use of a volatile base. Ammonia was used to adjust the pH of poly(acrylic acid) (PAA) so that direct complexation was avoided when it was mixed with polyethylenimine (PEI). Different charge ratios of homogeneous PEI/PAA solutions were successfully prepared and phase diagrams varying the concentration of ammonia or polyelectrolyte were made to study the phase behavior of PEI, PAA, and ammonia in water. Transparent ∼1 μm thick films were successfully deposited on biaxially orientated polypropylene (BOPP) sheets using a Meyer rod. After casting the films, the decrease in pH, caused by the evaporation of ammonia, triggered the complexation during drying. The oxygen permeation properties of films with different ratios and single polyelectrolytes were tested. All films displayed excellent oxygen barrier properties, with an oxygen permeation below 4 cm³·m^-2·day^-1·atm^-1 (<0.002 barrer) at the optimum ratio of 2:1 PEI/PAA. This ammonia evaporation-induced complexation approach creates a new pathway to prepare PEC films in one simple step while allowing the possibility of recycling.

SUBMITTER: Li J

PROVIDER: S-EPMC8153532 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib.

Project description:To overcome the high relapse rate of multiple myeloma (MM), a drug delivery coating for functionalization of bone substitution materials (BSM) is reported based on adhesive, catechol-containing and stimuli-responsive polyelectrolyte complexes (PECs). This system is designed to deliver the MM drug bortezomib (BZM) directly to the anatomical site of action. To establish a gradual BZM release, the naturally occurring caffeic acid (CA) is coupled oxidatively to form poly(caffeic acid) (PCA), which is used as a polyanion for complexation. The catechol functionalities within the PCA are particularly suitable to form esters with the boronic acid group of the BZM, which are then cleaved in the body fluid to administer the drug. To achieve a more thorough control of the release, the thermoresponsive poly(N-isoproplyacrylamide-co-dimethylaminoethylmethacrylate) (P(NIPAM-co-DMAEMA)) was used as a polycation. Using turbidity measurements, it was proven that the lower critical solution temperature (LCST) character of this polymer was transferred to the PECs. Further special temperature dependent attenuated total reflection infrared spectroscopy (ATR-FTIR) showed that coatings formed by PEC immobilization exhibit a similar thermoresponsive performance. By loading the coatings with BZM and studying the release in a model system, via UV/Vis it was observed, that both aims, the retardation and the stimuli control of the release, were achieved.

| S-EPMC6928965 | biostudies-literature

Transparent Pullulan/Mica Nanocomposite Coatings with Outstanding Oxygen Barrier Properties.

Project description:This study presents a new bionanocomposite coating on poly(ethylene terephthalate) (PET) made of pullulan and synthetic mica. Mica nanolayers have a very high aspect ratio (?), at levels much greater than that of conventional exfoliated clay layers (e.g., montmorillonite). A very small amount of mica (0.02 wt %, which is ? ? 0.00008) in pullulan coatings dramatically improved the oxygen barrier performance of the nanocomposite films under dry conditions, however, this performance was partly lost as the environmental relative humidity (RH) increased. This outcome was explained in terms of the perturbation of the spatial ordering of mica sheets within the main pullulan phase, because of RH fluctuations. This was confirmed by modelling of the experimental oxygen transmission rate (OTR) data according to Cussler's model. The presence of the synthetic nanobuilding block (NBB) led to a decrease in both static and kinetic coefficients of friction, compared with neat PET (?12% and 23%, respectively) and PET coated with unloaded pullulan (?26% reduction in both coefficients). In spite of the presence of the filler, all of the coating formulations did not significantly impair the overall optical properties of the final material, which exhibited haze values below 3% and transmittance above 85%. The only exception to this was represented by the formulation with the highest loading of mica (1.5 wt %, which is ? ? 0.01). These findings revealed, for the first time, the potential of the NBB mica to produce nanocomposite coatings in combination with biopolymers for the generation of new functional features, such as transparent high oxygen barrier materials.

| S-EPMC5618392 | biostudies-literature

Hybrid Gibbsite Nanoplatelet/Cellulose Nanocrystal Multilayered Coatings for Oxygen Barrier Improvement.

Project description:We have investigated the ability of multilayered hybrid thin films of cellulose nanocrystals (CNCs) and gibbsite nanoplatelets (GNPs) to be built by the layer-by-layer (LbL) technique onto substrates selected for packaging applications, and to improve the oxygen barrier properties. Using complementary structural characterization techniques, namely atomic force microscopy, ellipsometry, and spectral reflectance, we show that when deposited onto model silicon substrates these hybrid films were homogenous and of reduced porosity, and were comprised of alternately deposited monolayers of GNPs and CNCs. The successful deposition of such homogeneous and dense hybrid thin films onto various types of flexible substrates showing different chemical compositions, hydrophilicity, and surface morphology, ranging from cardboard to smart paper, polyethylene (PE) films, and PE-coated cardboard was also confirmed by scanning electron microscopy observations. In view of the diversity of these substrates we could confirm the remarkable robustness of such a deposition process, likely due to (i) the adaptability of the LbL assembling technique and (ii) the strong electrostatic and hydrogen bonding interactions between GNPs and CNCs. The measurement of the oxygen transmission rate (OTR) at 23°C and 50% RH showed that the oxygen barrier properties of the bare substrates could be significantly improved (e.g., 75% decrease of the OTR) after the deposition of such thin (<100 nm) multilayered hybrid films. This lowered permeability was tentatively attributed to the highly tortuous morphology of the coating, acting to impede the gas diffusion. These partially biosourced very thin films stand as good candidates for using as coatings showing high oxygen barrier performance.

| S-EPMC6650769 | biostudies-literature

Single-Step Fabrication of Polymer Nanocomposite Films.

Project description:Polymer nanocomposites are employed in (micro)electronic, biomedical, structural and optical applications. Their fabrication is challenging due to nanoparticle (filler) agglomeration and settling, increased viscosity of blended solutions and multiple tedious processing steps, just to name a few. Often this leads to an upper limit for filler content, requirements for filler?polymer interfacial chemistry and expensive manufacturing. As a result, novel but simple processes for nanocomposite manufacture that overcome such hurdles are needed. Here, a truly single-step procedure for synthesis of polymer nanocomposite films, structures and patterns at high loadings of nanoparticles (for example, >24 vol %) for a variety of compositions is presented. It is highly versatile with respect to rapid preparation of films possessing multiple layers and filler content gradients even on untreated challenging substrates (paper, glass, polymers). Such composites containing homogeneously dispersed nanoparticles even at high loadings can improve the mechanical strength of hydrogels, load-bearing ability of fragile microstructures, gas permeability in thin barriers, performance of dielectrics and device integration in stretchable electronics.

| S-EPMC6073108 | biostudies-literature

Synthesis and Crystallization of Waterborne Thiol-ene Polymers: Toward Innovative Oxygen Barrier Coatings.

Project description:The synthesis of waterborne thiol-ene polymer dispersions is challenging due to the high reactivity of thiol monomers and the premature thiol-ene polymerization that leads to high irreproducibility. By turning this challenge into an advantage, a synthesis approach of high solid content film-forming waterborne poly(thioether) prepolymers is reported based on initiator-free step growth sonopolymerization. Copolymerization of bifunctional thiol and ene monomers diallyl terephthalate, glycol dimercaptoacetate, glycol dimercaptopropionate, and 2,2-(ethylenedioxy)diethanethiol gave rise to linear poly(thioether) functional chains with molar mass ranging between 7 and 23 kDa when synthesized at 30% solid content and between 1 and 9 kDa at increased solid content of 50%. To further increase the polymers' molar mass, an additional photopolymerization step was performed in the presence of a water-soluble photoinitiator, i.e., lithium phenyl-2,4,6-trimethylbenzoylphosphinate, leading to high molar mass chains of up to 200 kDa, the highest reported so far for step grown poly(thioethers). The polymer dispersions presented good film-forming ability at room temperature, yielding semicrystalline films with a high potential for barrier coating applications. Nevertheless, affected by the polymer chemical repeating structure, which includes an aromatic ring, these thiol-ene chains can only crystallize very slowly from the molten state. Herein, for the first time, we present the successful implementation of a self-nucleation (SN) procedure for these types of poly(thioethers), which effectively accelerates their crystallization kinetics.

| S-EPMC10644330 | biostudies-literature

Nanotemplated polyelectrolyte films as porous biomolecular delivery systems. Application to the growth factor BMP-2.

Project description:Biomaterials capable of delivering controlled quantities of bioactive agents, while maintaining mechanical integrity, are needed for a variety of cell contacting applications. We describe here a nanotemplating strategy toward porous, polyelectrolyte-based thin films capable of controlled biomolecular loading and release. Films are formed via the layer-by-layer assembly of charged polymers and nanoparticles (NP), then chemically cross-linked to increase mechanical rigidity and stability, and finally exposed to tetrahydrofuran to dissolve the NP and create an intra-film porous network. We report here on the loading and release of the growth factor bone morphogenetic protein 2 (BMP-2), and the influence of BMP-2 loaded films on contacting murine C2C12 myoblasts. We observe nanotemplating to enable stable BMP-2 loading throughout the thickness of the film, and find the nanotemplated film to exhibit comparable cell adhesion, and enhanced cell differentiation, compared with a non-porous cross-linked film (where BMP-2 loading is mainly confined to the film surface).

| S-EPMC4122565 | biostudies-literature

Stimuli-Responsive Nanodiamond-Polyelectrolyte Composite Films.

Project description:Nanodiamonds (NDs) can considerably improve the mechanical and thermal properties of polymeric composites. However, the tendency of NDs to aggregate limits the potential of these non-toxic, mechanically- and chemically-robust nanofillers. In this work, tough, flexible, and stimuli-responsive polyelectrolyte films composed of cross-linked poly(butyl acrylate-co-dimethylaminoethyl methacrylate) (P(BA-co-DMAEMA)) were prepared by photopolymerization. The effects of the added carboxylate-functionalized NDs on their mechanical and stimuli-responsive properties were studied. When the negatively charged NDs were added to the polymerization media directly, the mechanical properties of the films changed only slightly, because of the uneven distribution of the aggregated NDs in the films. In order to disperse and distribute the NDs more evenly, a prepolymerized polycation block copolymer complexing agent was used during the photopolymerization process. This approach improved the mechanical properties of the films and enhanced their thermally-induced, reversible phase-transition behavior.

| S-EPMC7182812 | biostudies-literature

Comparison of Crosslinking Efficiency in Dip and Roll-Deposited Coatings on Their Oxygen Barrier.

Project description:Coating techniques are key factors in determining coated film properties. In the present study, nanocomposite coatings of poly(vinyl alcohol) and a nanoclay, montmorillonite, were deposited layer-by-layer using roll (doctor blade, DB) and dip coating techniques, in an effort to compare the impact of these techniques on the crosslinking efficiency and oxygen barrier of the coated films. The barrier properties at different relative humidities were tested, and the extent of nanoclay intercalation as well as the films' morphology was investigated. Barrier was further improved by crosslinking the coating with glyoxal and glutaraldehyde. Both techniques gave similar results but with a higher impact of relative humidity in roll coated films. Better results were achieved by tailoring the composition of those coatings to favor a higher density of hydrogen bonding in the coating.

| S-EPMC6777300 | biostudies-literature

Polyelectrolyte-Assisted Dispersions of Reduced Graphite Oxide Nanoplates in Water and Their Gas-Barrier Application.

Project description:Dispersion of graphene and related materials in water is needed to enable sustainable processing of these 2D materials. In this work, we demonstrate the capability of branched polyethylenimine (BPEI) and polyacrylic acid (PAA) to stabilize reduced graphite oxide (rGO) dispersions in water. Atomic force microscopy colloidal probe measurements were carried out to investigate the interaction mechanisms between rGO and the polyelectrolytes (PEs). Our results show that for positive PEs, the interaction appears electrostatic, originating from the weak negative charge of graphene in water. For negative PEs, however, van der Waals forces may result in the formation of a PE shell on rGO. The PE-stabilized rGO dispersions were then used for the preparation of coatings to enhance gas barrier properties of polyethylene terephthalate films using the layer-by-layer self-assembly. Ten bilayers of rGOBPEI/rGOPAA resulted in coatings with excellent barrier properties as demonstrated by oxygen transmission rates below detection limits [<0.005 cm3/(m2 day atm)]. The observed excellent performance is ascribed to both the high density of the deposited coating and its efficient stratification. These results can enable the design of highly efficient gas barrier solutions for demanding applications, including oxygen-sensitive pharmaceutical products or flexible electronic devices.

| S-EPMC8447182 | biostudies-literature

The stability of BMP loaded polyelectrolyte multilayer coatings on titanium.

Project description:Immobilization of bone morphogenetic proteins (BMP) onto material surfaces is a promising, but still challenging, strategy for achieving dependable and consistent osseointegration of long-term metal implants. In the present study, we have developed an osteoinductive coating of a porous titanium implant using biomimetic polyelectrolyte multilayer (PEM) films loaded with BMP-2. The amount of BMP-2 loaded in these films was tuned - over a large range - depending on the cross-linking extent of the film and of the BMP-2 initial concentration. The air-dried PEM films were stable for at least one year of storage at 4 °C. In addition, they resisted exposure to ?-irradiation at clinically approved doses. The preservation of the growth factor bioactivity upon long-term storage and sterilization were evaluated both in vitro (using C2C12 cells) and in vivo (in a rat ectopic model) for the perspective of industrial and clinical development. BMP-2 loaded in dried PEM films exhibited shelf-life stability over one year. However, their bioactivity in vitro decreased from 50 to 80% after irradiation depending on the ?-irradiation dose. Remarkably, the in vivo studies showed that the osteoinductive potential of BMP-2 contained in PEM-coated Ti implants was fully preserved after air-drying of the implants and sterilization at 25 kGy. Film drying or irradiation did not affect the amount of new bone tissue formation. This "off-the-shelf" novel technology of functionalized implants opens promising applications in prosthetic and tissue engineering fields.

| S-EPMC4119881 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data