Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer.
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ABSTRACT:
SUBMITTER: Xia Z
PROVIDER: S-EPMC8153951 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer.
Xia Zhengxiang Z Tang Zhongyan Z
ACS omega 20210414 16
Endometrial cancer (EC) is one of the three most common gynecological cancers in female groups. Gambogic acid (GA), a natural caged xanthone, exerts significantly antitumor effects on many cancers. However, its efficacy on EC and pharmacological mechanism of action remain marginal up to now. This study suggested that GA had significant inhibitory effects on EC in vitro and in vivo, and no toxicity to normal cells or mice. In detail, GA suppressed cell proliferation, induced cell apoptosis, and c ...[more]
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