Prediction of MDMA response in healthy humans: a pooled analysis of placebo-controlled studies.

ABSTRACT:

Background

3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is used both recreationally and therapeutically. Little is known about the factors influencing inter- and intra-individual differences in the acute response to MDMA. Effects of other psychoactive substances have been shown to be critically influenced by personality traits and mood state before intake.

Methods

We pooled data from 10 randomized, double-blind, placebo-controlled, cross-over studies performed in the same laboratory in 194 healthy subjects receiving doses of 75 or 125mg of MDMA. We investigated the influence of drug dose, body weight, sex, age, drug pre-experience, genetics, personality and mental state before drug intake on the acute physiological and psychological response to MDMA.

Results

In

SUBMITTER: Studerus E 

PROVIDER: S-EPMC8155734 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature